Biochemical Studies on Adenovirus Multiplication
نویسندگان
چکیده
منابع مشابه
Biochemical Studies on Adenovirus Multiplication. v. Enzymes of Deoxyribonucleic Acid Synthesis in Cells Infected by Adenovirus and Vaccinia Virus.
The mechanism of viral DNA synthesis may be expected to depend on the particular virus in question, i.e. its size and composition, genetic potentiality, rate of multiplication, intracellular site of multiplication, etc. Several possible mechanisms can be envisioned for the biosynthesis of viral DNA: (a) the “DNAsynthesizing enayme”1 system of the host cell may be utilized without modification; ...
متن کاملBiochemical studies on adenovirus multiplication, xi. Evidence of a cytoplasmic site for the synthesis of viral-coded proteins.
Available evidence indicates that adenoviruses are assembled in the cell nucleus.'-4 However, the question of the site of synthesis of viral-specific proteins is not settled. Data reported here provide strong presumptive evidence that adenovirus-coded proteins, like cellular proteins, are made in the cell cytoplasm on polyribosomes. Materials and Methods.-The methods described by Green and Pifi...
متن کاملBiochemical studies on adenovirus multiplication, XIX. Resolution of late viral RNA species in the nucleus and cytoplasm.
Late after infection of cultured human cells (KB) with adenovirus type 2, the nucleus contains heterogeneous viral RNA species ranging in size from 10 to 43 S. Four viral RNA species found in the nucleus (36, 38, 40, and 43 S) are synthesized predominantly during a 15-min labeling period with [(3)H]uridine, while smaller RNA species accumulate when labeling is continued for longer periods. In c...
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The susceptibility of adenovirus to the inhibitory effect of human interferons in vitro was investigated. We tested recombinant human interferons-c~2, -/~1 and -7 against adenovirus serotypes 1 and 5 (group C), 3 and 7a (group B), and a wild strain isolated from an acutely ill child who later died. Pretreatment of WISH cells with interferon-? for 24 h induced a dose-dependent inhibition of mult...
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During and following the production of shock by hemorrhage in the normal, suprareno-demedullated, and suprarenalectomized rat, the following significant changes in amino acid and carbohydrate metabolism have been observed. 1. In the intact, suprareno-demedullated, and suprarenalectomized rat there is a progressive rise in the whole blood and plasma amino acid nitrogen levels during and after a ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1964
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)91410-9